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Lanoconazole

CAS No. 101530-10-3

Lanoconazole ( —— )

产品货号. M25038 CAS No. 101530-10-3

拉诺康唑是一种有效的口服活性咪唑抗真菌剂,在体外和体内表现出广谱的抗真菌活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥612 有现货
10MG ¥1044 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Lanoconazole
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    拉诺康唑是一种有效的口服活性咪唑抗真菌剂,在体外和体内表现出广谱的抗真菌活性。
  • 产品描述
    Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis. Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose‐dependently suppresses TPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte‐derived chemokine and macrophage inflammatory protein‐2, and inhibited neutrophil infiltration to the inflammation site. Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice.
  • 体外实验
    ——
  • 体内实验
    Animal Model:BALB/c miceDosage:0.3%-3% dosage Administration:Treatment for earResult:Exhibited an inhibition effect of LCZ on ear swelling induced by topical application of TPA in mice. Animal Model:Four week old C57BL/6 mice infected intraperitoneally with LP-BM5 murine leukaemia virus Dosage:3, 10 or 30 mg/kg Administration:Oral adminstration Result:Inhibited C. neoformans? growth in both normal and C. neoformans?-induced encephalitis MAIDS mice .
  • 同义词
    ——
  • 通路
    Microbiology/Virology
  • 靶点
    Fungal
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    101530-10-3
  • 分子量
    319.83
  • 分子式
    C14H10ClN3S2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 100 mg/mL (312.67 mM; Need ultrasonic)
  • SMILES
    N#C/C(N1C=CN=C1)=C2SC(C(C=CC=C3)=C3Cl)CS\2.[(E)]
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Shokoohi GR, et al. In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives.Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00635-17. 2. Nakamura A, et al. Anti-inflammatory effect of lanoconazole on 12-O-tetradecanoylphorbol-13-acetate- and 2,4,6-trinitrophenyl chloride-induced skin inflammation in mice.Mycoses. 2020 Feb;63(2):189-196. 3. Furukawa K, et al. Lanoconazole, a new imidazole antimycotic compound, protects MAIDS mice against encephalitis caused by Cryptococcus neoformans.J Antimicrob Chemother. 2000 Sep;46(3):443-50.
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